The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NLRP4-20-RE | 20 (40 μL) | 200 μL |  |
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| NLRP4-20-OR | 20 (40 μL) | 200 μL |  |
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| NLRP4-20-GO | 20 (40 μL) | 200 μL |  |
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| NLRP4-20-GR | 20 (40 μL) | 200 μL |  |
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| NLRP4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
Gene Symbol : NLRP4
Gene Name : NLR family pyrin domain containing 4
Chromosome : CHR 19: 558,365,77-558,818,54
Locus : 19q13.43
Alt. Genes : RGS19
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