This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NME1-20-RE | 20 (40 μL) | 200 μL |  |
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| NME1-20-OR | 20 (40 μL) | 200 μL |  |
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| NME1-20-GO | 20 (40 μL) | 200 μL |  |
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| NME1-20-GR | 20 (40 μL) | 200 μL |  |
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| NME1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Gene Symbol : NME1
Gene Name : NME/NM23 nucleoside diphosphate kinase 1
Chromosome : CHR 17: 511,535,58-511,620,88
Locus : 17q21.33
Alt. Genes : KLHL41
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