This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NPR2-20-RE | 20 (40 μL) | 200 μL |  |
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| NPR2-20-OR | 20 (40 μL) | 200 μL |  |
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| NPR2-20-GO | 20 (40 μL) | 200 μL |  |
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| NPR2-20-GR | 20 (40 μL) | 200 μL |  |
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| NPR2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Gene Symbol : NPR2
Gene Name : Natriuretic peptide receptor 2
Chromosome : CHR 9: 357,529,44-358,097,30
Locus : 9p13.3
Alt. Genes : HIPK3
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