This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NRAS-20-RE | 20 (40 μL) | 200 μL |  |
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| NRAS-20-OR | 20 (40 μL) | 200 μL |  |
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| NRAS-20-GO | 20 (40 μL) | 200 μL |  |
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| NRAS-20-GR | 20 (40 μL) | 200 μL |  |
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| NRAS-20-AQ | 20 (40 μL) | 200 μL |  |
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This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Gene Symbol : NRAS
Gene Name : NRAS proto-oncogene, GTPase
Chromosome : CHR 1: 114,716,893-114,704,463
Locus : 1p13.2
Alt. Genes : ABI2
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