This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NUDT15-20-RE | 20 (40 μL) | 200 μL |  |
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| NUDT15-20-OR | 20 (40 μL) | 200 μL |  |
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| NUDT15-20-GO | 20 (40 μL) | 200 μL |  |
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| NUDT15-20-GR | 20 (40 μL) | 200 μL |  |
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| NUDT15-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
Gene Symbol : NUDT15
Gene Name : Nudix hydrolase 15
Chromosome : CHR 13: 480,375,66-480,527,41
Locus : 13q14.2
Alt. Genes : SGK2
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