This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OAS2-20-RE | 20 (40 μL) | 200 μL |  |
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| OAS2-20-OR | 20 (40 μL) | 200 μL |  |
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| OAS2-20-GO | 20 (40 μL) | 200 μL |  |
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| OAS2-20-GR | 20 (40 μL) | 200 μL |  |
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| OAS2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : OAS2
Gene Name : 2'-5'-oligoadenylate synthetase 2
Chromosome : CHR 12: 112,978,394-113,011,722
Locus : 12q24.13
Alt. Genes : LILRB2
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