The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OBSCN-20-RE | 20 (40 μL) | 200 μL |  |
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| OBSCN-20-OR | 20 (40 μL) | 200 μL |  |
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| OBSCN-20-GO | 20 (40 μL) | 200 μL |  |
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| OBSCN-20-GR | 20 (40 μL) | 200 μL |  |
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| OBSCN-20-AQ | 20 (40 μL) | 200 μL |  |
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The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Symbol : OBSCN
Gene Name : Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Chromosome : CHR 1: 228,208,012-228,381,430
Locus : 1q42.13
Alt. Genes : CEBPZ
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