The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OTUB1-20-RE | 20 (40 μL) | 200 μL |  |
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| OTUB1-20-OR | 20 (40 μL) | 200 μL |  |
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| OTUB1-20-GO | 20 (40 μL) | 200 μL |  |
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| OTUB1-20-GR | 20 (40 μL) | 200 μL |  |
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| OTUB1-20-AQ | 20 (40 μL) | 200 μL |  |
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The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Symbol : OTUB1
Gene Name : OTU deubiquitinase, ubiquitin aldehyde binding 1
Chromosome : CHR 11: 639,858,52-639,984,19
Locus : 11q13.1
Alt. Genes : YAF2
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