This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OTUD5-20-RE | 20 (40 μL) | 200 μL |  |
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| OTUD5-20-OR | 20 (40 μL) | 200 μL |  |
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| OTUD5-20-GO | 20 (40 μL) | 200 μL |  |
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| OTUD5-20-GR | 20 (40 μL) | 200 μL |  |
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| OTUD5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Symbol : OTUD5
Gene Name : OTU deubiquitinase 5
Chromosome : CHR X: 489,583,85-489,220,23
Locus : Xp11.23
Alt. Genes : OPTN
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