This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PACS1-20-RE | 20 (40 μL) | 200 μL |  |
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| PACS1-20-OR | 20 (40 μL) | 200 μL |  |
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| PACS1-20-GO | 20 (40 μL) | 200 μL |  |
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| PACS1-20-GR | 20 (40 μL) | 200 μL |  |
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| PACS1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Symbol : PACS1
Gene Name : Phosphofurin acidic cluster sorting protein 1
Chromosome : CHR 11: 660,702,75-662,447,46
Locus : 11q13.1-q13.2
Alt. Genes : BCAP31
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