This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAM-20-RE | 20 (40 μL) | 200 μL |  |
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| PAM-20-OR | 20 (40 μL) | 200 μL |  |
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| PAM-20-GO | 20 (40 μL) | 200 μL |  |
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| PAM-20-GR | 20 (40 μL) | 200 μL |  |
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| PAM-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Symbol : PAM
Gene Name : Peptidylglycine alpha-amidating monooxygenase
Chromosome : CHR 5: 102,754,782-103,031,104
Locus : 5q21.1
Alt. Genes : OPTN
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