This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAPPA-20-RE | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-OR | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-GO | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-GR | 20 (40 μL) | 200 μL |  |
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| PAPPA-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Gene Symbol : PAPPA
Gene Name : Pappalysin 1
Chromosome : CHR 9: 116,153,751-116,402,320
Locus : 9q33.1
Alt. Genes : LRPPRC
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