This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAX3-20-RE | 20 (40 μL) | 200 μL |  |
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| PAX3-20-OR | 20 (40 μL) | 200 μL |  |
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| PAX3-20-GO | 20 (40 μL) | 200 μL |  |
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| PAX3-20-GR | 20 (40 μL) | 200 μL |  |
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| PAX3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]
Gene Symbol : PAX3
Gene Name : Paired box 3
Chromosome : CHR 2: 222,298,995-222,199,886
Locus : 2q36.1
Alt. Genes : EBI3
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