This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDCD1-20-RE | 20 (40 μL) | 200 μL |  |
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| PDCD1-20-OR | 20 (40 μL) | 200 μL |  |
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| PDCD1-20-GO | 20 (40 μL) | 200 μL |  |
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| PDCD1-20-GR | 20 (40 μL) | 200 μL |  |
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| PDCD1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Gene Symbol : PDCD1
Gene Name : Programmed cell death 1
Chromosome : CHR 2: 241,858,907-241,849,880
Locus : 2q37.3
Alt. Genes : WASF2
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