This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDCD6-20-RE | 20 (40 μL) | 200 μL |  |
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| PDCD6-20-OR | 20 (40 μL) | 200 μL |  |
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| PDCD6-20-GO | 20 (40 μL) | 200 μL |  |
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| PDCD6-20-GR | 20 (40 μL) | 200 μL |  |
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| PDCD6-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
Gene Symbol : PDCD6
Gene Name : Programmed cell death 6
Chromosome : CHR 5: 271,620-314,973
Locus : 5p15.33
Alt. Genes : SGK2
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