The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDE11A-20-RE | 20 (40 μL) | 200 μL |  |
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| PDE11A-20-OR | 20 (40 μL) | 200 μL |  |
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| PDE11A-20-GO | 20 (40 μL) | 200 μL |  |
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| PDE11A-20-GR | 20 (40 μL) | 200 μL |  |
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| PDE11A-20-AQ | 20 (40 μL) | 200 μL |  |
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The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : PDE11A
Gene Name : Phosphodiesterase 11A
Chromosome : CHR 2: 178,108,338-177,623,248
Locus : 2q31.2
Alt. Genes : LRPPRC
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