PDE6A FISH Probe

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
PDE6A-20-RE 20 (40 μL) 200 μL color Request Pricing
PDE6A-20-OR 20 (40 μL) 200 μL color Request Pricing
PDE6A-20-GO 20 (40 μL) 200 μL color Request Pricing
PDE6A-20-GR 20 (40 μL) 200 μL color Request Pricing
PDE6A-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : PDE6A

Gene Name : Phosphodiesterase 6A

Chromosome : CHR 5: 149,944,792-149,857,955

Locus : 5q32

Alt. Genes : SUGP2

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