Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDE6B-20-RE | 20 (40 μL) | 200 μL |  |
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| PDE6B-20-OR | 20 (40 μL) | 200 μL |  |
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| PDE6B-20-GO | 20 (40 μL) | 200 μL |  |
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| PDE6B-20-GR | 20 (40 μL) | 200 μL |  |
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| PDE6B-20-AQ | 20 (40 μL) | 200 μL |  |
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Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Symbol : PDE6B
Gene Name : Phosphodiesterase 6B
Chromosome : CHR 4: 587,592-670,891
Locus : 4p16.3
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