This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDIA2-20-RE | 20 (40 μL) | 200 μL |  |
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| PDIA2-20-OR | 20 (40 μL) | 200 μL |  |
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| PDIA2-20-GO | 20 (40 μL) | 200 μL |  |
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| PDIA2-20-GR | 20 (40 μL) | 200 μL |  |
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| PDIA2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]
Gene Symbol : PDIA2
Gene Name : Protein disulfide isomerase family A member 2
Chromosome : CHR 16: 283,117-287,208
Locus : 16p13.3
Alt. Genes : TRIM28
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