The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDX1-20-RE | 20 (40 μL) | 200 μL |  |
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| PDX1-20-OR | 20 (40 μL) | 200 μL |  |
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| PDX1-20-GO | 20 (40 μL) | 200 μL |  |
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| PDX1-20-GR | 20 (40 μL) | 200 μL |  |
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| PDX1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]
Gene Symbol : PDX1
Gene Name : Pancreatic and duodenal homeobox 1
Chromosome : CHR 13: 279,199,81-279,263,13
Locus : 13q12.2
Alt. Genes : PREB
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