Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDZD3-20-RE | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-OR | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-GO | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-GR | 20 (40 μL) | 200 μL |  |
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| PDZD3-20-AQ | 20 (40 μL) | 200 μL |  |
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Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Gene Symbol : PDZD3
Gene Name : PDZ domain containing 3
Chromosome : CHR 11: 119,185,456-119,190,222
Locus : 11q23.3
Alt. Genes : CELA3A
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