This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PFKFB1-20-RE | 20 (40 μL) | 200 μL |  |
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| PFKFB1-20-OR | 20 (40 μL) | 200 μL |  |
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| PFKFB1-20-GO | 20 (40 μL) | 200 μL |  |
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| PFKFB1-20-GR | 20 (40 μL) | 200 μL |  |
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| PFKFB1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Symbol : PFKFB1
Gene Name : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Chromosome : CHR X: 549,985,33-549,331,33
Locus : Xp11.21
Alt. Genes : SUGP2
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