The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PHOX2B-20-RE | 20 (40 μL) | 200 μL |  |
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| PHOX2B-20-OR | 20 (40 μL) | 200 μL |  |
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| PHOX2B-20-GO | 20 (40 μL) | 200 μL |  |
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| PHOX2B-20-GR | 20 (40 μL) | 200 μL |  |
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| PHOX2B-20-AQ | 20 (40 μL) | 200 μL |  |
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The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
Gene Symbol : PHOX2B
Gene Name : Paired like homeobox 2b
Chromosome : CHR 4: 417,489,69-417,440,81
Locus : 4p13
Alt. Genes : OPTN
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