This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PKM-20-RE | 20 (40 μL) | 200 μL |  |
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| PKM-20-OR | 20 (40 μL) | 200 μL |  |
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| PKM-20-GO | 20 (40 μL) | 200 μL |  |
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| PKM-20-GR | 20 (40 μL) | 200 μL |  |
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| PKM-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
Gene Symbol : PKM
Gene Name : Pyruvate kinase M1/2
Chromosome : CHR 15: 722,316,23-721,990,28
Locus : 15q23
Alt. Genes : CLEC3A
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