The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLA2G12B-20-RE | 20 (40 μL) | 200 μL |  |
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| PLA2G12B-20-OR | 20 (40 μL) | 200 μL |  |
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| PLA2G12B-20-GO | 20 (40 μL) | 200 μL |  |
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| PLA2G12B-20-GR | 20 (40 μL) | 200 μL |  |
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| PLA2G12B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Symbol : PLA2G12B
Gene Name : Phospholipase A2 group XIIB
Chromosome : CHR 10: 729,550,43-729,347,61
Locus : 10q22.1
Alt. Genes : DNAL4
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