This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLA2G3-20-RE | 20 (40 μL) | 200 μL |  |
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| PLA2G3-20-OR | 20 (40 μL) | 200 μL |  |
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| PLA2G3-20-GO | 20 (40 μL) | 200 μL |  |
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| PLA2G3-20-GR | 20 (40 μL) | 200 μL |  |
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| PLA2G3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
Gene Symbol : PLA2G3
Gene Name : Phospholipase A2 group III
Chromosome : CHR 22: 311,406,06-311,348,06
Locus : 22q12.2
Alt. Genes : CEBPZ
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