This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLAGL1-20-RE | 20 (40 μL) | 200 μL |  |
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| PLAGL1-20-OR | 20 (40 μL) | 200 μL |  |
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| PLAGL1-20-GO | 20 (40 μL) | 200 μL |  |
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| PLAGL1-20-GR | 20 (40 μL) | 200 μL |  |
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| PLAGL1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Gene Symbol : PLAGL1
Gene Name : PLAG1 like zinc finger 1
Chromosome : CHR 6: 144,064,598-143,940,299
Locus : 6q24.2
Alt. Genes : PLXNC1
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