This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLCD3-20-RE | 20 (40 μL) | 200 μL |  |
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| PLCD3-20-OR | 20 (40 μL) | 200 μL |  |
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| PLCD3-20-GO | 20 (40 μL) | 200 μL |  |
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| PLCD3-20-GR | 20 (40 μL) | 200 μL |  |
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| PLCD3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Gene Symbol : PLCD3
Gene Name : Phospholipase C delta 3
Chromosome : CHR 17: 451,325,32-451,116,39
Locus : 17q21.31
Alt. Genes : ZNF263
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