Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLOD1-20-RE | 20 (40 μL) | 200 μL |  |
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| PLOD1-20-OR | 20 (40 μL) | 200 μL |  |
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| PLOD1-20-GO | 20 (40 μL) | 200 μL |  |
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| PLOD1-20-GR | 20 (40 μL) | 200 μL |  |
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| PLOD1-20-AQ | 20 (40 μL) | 200 μL |  |
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Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Symbol : PLOD1
Gene Name : Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Chromosome : CHR 1: 119,346,66-119,755,41
Locus : 1p36.22
Alt. Genes : TRAP1
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