The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLOD3-20-RE | 20 (40 μL) | 200 μL |  |
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| PLOD3-20-OR | 20 (40 μL) | 200 μL |  |
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| PLOD3-20-GO | 20 (40 μL) | 200 μL |  |
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| PLOD3-20-GR | 20 (40 μL) | 200 μL |  |
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| PLOD3-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Gene Symbol : PLOD3
Gene Name : Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Chromosome : CHR 7: 101,217,729-101,205,976
Locus : 7q22.1
Alt. Genes : LINC01587
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