This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PMEL-20-RE | 20 (40 μL) | 200 μL |  |
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| PMEL-20-OR | 20 (40 μL) | 200 μL |  |
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| PMEL-20-GO | 20 (40 μL) | 200 μL |  |
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| PMEL-20-GR | 20 (40 μL) | 200 μL |  |
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| PMEL-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Gene Symbol : PMEL
Gene Name : Premelanosome protein
Chromosome : CHR 12: 559,667,11-559,541,04
Locus : 12q13.2
Alt. Genes : OPTN
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