This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POLD2-20-RE | 20 (40 μL) | 200 μL |  |
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| POLD2-20-OR | 20 (40 μL) | 200 μL |  |
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| POLD2-20-GO | 20 (40 μL) | 200 μL |  |
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| POLD2-20-GR | 20 (40 μL) | 200 μL |  |
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| POLD2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Gene Symbol : POLD2
Gene Name : DNA polymerase delta 2, accessory subunit
Chromosome : CHR 7: 441,236,67-441,146,79
Locus : 7p13
Alt. Genes : RAD50
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