This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POLG2-20-RE | 20 (40 μL) | 200 μL |  |
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| POLG2-20-OR | 20 (40 μL) | 200 μL |  |
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| POLG2-20-GO | 20 (40 μL) | 200 μL |  |
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| POLG2-20-GR | 20 (40 μL) | 200 μL |  |
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| POLG2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]
Gene Symbol : POLG2
Gene Name : DNA polymerase gamma 2, accessory subunit
Chromosome : CHR 17: 644,970,65-644,777,84
Locus : 17q23.3
Alt. Genes : OPTN
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