This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POLR2A-20-RE | 20 (40 μL) | 200 μL |  |
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| POLR2A-20-OR | 20 (40 μL) | 200 μL |  |
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| POLR2A-20-GO | 20 (40 μL) | 200 μL |  |
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| POLR2A-20-GR | 20 (40 μL) | 200 μL |  |
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| POLR2A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
Gene Symbol : POLR2A
Gene Name : RNA polymerase II subunit A
Chromosome : CHR 17: 748,437,8-751,461,7
Locus : 17p13.1
Alt. Genes : LRPPRC
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