This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRAME-20-RE | 20 (40 μL) | 200 μL |  |
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| PRAME-20-OR | 20 (40 μL) | 200 μL |  |
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| PRAME-20-GO | 20 (40 μL) | 200 μL |  |
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| PRAME-20-GR | 20 (40 μL) | 200 μL |  |
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| PRAME-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Symbol : PRAME
Gene Name : Preferentially expressed antigen in melanoma
Chromosome : CHR 22: 225,597,64-225,476,95
Locus : 22q11.22
Alt. Genes : GPHN
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