The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRKAA1-20-RE | 20 (40 μL) | 200 μL |  |
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| PRKAA1-20-OR | 20 (40 μL) | 200 μL |  |
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| PRKAA1-20-GO | 20 (40 μL) | 200 μL |  |
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| PRKAA1-20-GR | 20 (40 μL) | 200 μL |  |
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| PRKAA1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Symbol : PRKAA1
Gene Name : Protein kinase AMP-activated catalytic subunit alpha 1
Chromosome : CHR 5: 407,981,94-407,593,78
Locus : 5p13.1
Alt. Genes : SGK2
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