PRSS2 FISH Probe

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
PRSS2-20-RE 20 (40 μL) 200 μL color Request Pricing
PRSS2-20-OR 20 (40 μL) 200 μL color Request Pricing
PRSS2-20-GO 20 (40 μL) 200 μL color Request Pricing
PRSS2-20-GR 20 (40 μL) 200 μL color Request Pricing
PRSS2-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Gene Details

Gene Symbol : PRSS2

Gene Name : Protease, serine 2

Chromosome : CHR 7: 142,770,942-142,774,563

Locus : 7q34

Alt. Genes : TXNRD2

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