This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PRSS8-20-RE | 20 (40 μL) | 200 μL |  |
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| PRSS8-20-OR | 20 (40 μL) | 200 μL |  |
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| PRSS8-20-GO | 20 (40 μL) | 200 μL |  |
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| PRSS8-20-GR | 20 (40 μL) | 200 μL |  |
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| PRSS8-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
Gene Symbol : PRSS8
Gene Name : Protease, serine 8
Chromosome : CHR 16: 311,357,61-311,314,32
Locus : 16p11.2
Alt. Genes : PRMT3
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