The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PZP-20-RE | 20 (40 μL) | 200 μL |  |
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| PZP-20-OR | 20 (40 μL) | 200 μL |  |
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| PZP-20-GO | 20 (40 μL) | 200 μL |  |
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| PZP-20-GR | 20 (40 μL) | 200 μL |  |
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| PZP-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
Gene Symbol : PZP
Gene Name : PZP, alpha-2-macroglobulin like
Chromosome : CHR 12: 920,836,9-914,072,9
Locus : 12p13.31
Alt. Genes : CERS1
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