This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| QPRT-20-RE | 20 (40 μL) | 200 μL |  |
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| QPRT-20-OR | 20 (40 μL) | 200 μL |  |
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| QPRT-20-GO | 20 (40 μL) | 200 μL |  |
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| QPRT-20-GR | 20 (40 μL) | 200 μL |  |
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| QPRT-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Symbol : QPRT
Gene Name : Quinolinate phosphoribosyltransferase
Chromosome : CHR 16: 296,705,87-296,986,98
Locus : 16p11.2
Alt. Genes : CELA3A
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