Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAPGEF2-20-RE | 20 (40 μL) | 200 μL |  |
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| RAPGEF2-20-OR | 20 (40 μL) | 200 μL |  |
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| RAPGEF2-20-GO | 20 (40 μL) | 200 μL |  |
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| RAPGEF2-20-GR | 20 (40 μL) | 200 μL |  |
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| RAPGEF2-20-AQ | 20 (40 μL) | 200 μL |  |
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Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Gene Symbol : RAPGEF2
Gene Name : Rap guanine nucleotide exchange factor 2
Chromosome : CHR 4: 159,104,066-159,360,163
Locus : 4q32.1
Alt. Genes : MKRN3-AS1
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