This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RASA4-20-RE | 20 (40 μL) | 200 μL |  |
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| RASA4-20-OR | 20 (40 μL) | 200 μL |  |
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| RASA4-20-GO | 20 (40 μL) | 200 μL |  |
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| RASA4-20-GR | 20 (40 μL) | 200 μL |  |
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| RASA4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : RASA4
Gene Name : RAS p21 protein activator 4
Chromosome : CHR 7: 102,616,757-102,579,645
Locus : 7q22.1
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