RASGRF1 FISH Probe

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
RASGRF1-20-RE 20 (40 μL) 200 μL color Request Pricing
RASGRF1-20-OR 20 (40 μL) 200 μL color Request Pricing
RASGRF1-20-GO 20 (40 μL) 200 μL color Request Pricing
RASGRF1-20-GR 20 (40 μL) 200 μL color Request Pricing
RASGRF1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Gene Details

Gene Symbol : RASGRF1

Gene Name : Ras protein specific guanine nucleotide releasing factor 1

Chromosome : CHR 15: 790,908,72-789,599,46

Locus : 15q25.1

Alt. Genes : TRAP1

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