This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RASGRP1-20-RE | 20 (40 μL) | 200 μL |  |
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| RASGRP1-20-OR | 20 (40 μL) | 200 μL |  |
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| RASGRP1-20-GO | 20 (40 μL) | 200 μL |  |
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| RASGRP1-20-GR | 20 (40 μL) | 200 μL |  |
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| RASGRP1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Gene Symbol : RASGRP1
Gene Name : RAS guanyl releasing protein 1
Chromosome : CHR 15: 385,648,05-384,880,96
Locus : 15q14
Alt. Genes : LRPPRC
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