The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RBBP6-20-RE | 20 (40 μL) | 200 μL |  |
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| RBBP6-20-OR | 20 (40 μL) | 200 μL |  |
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| RBBP6-20-GO | 20 (40 μL) | 200 μL |  |
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| RBBP6-20-GR | 20 (40 μL) | 200 μL |  |
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| RBBP6-20-AQ | 20 (40 μL) | 200 μL |  |
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The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : RBBP6
Gene Name : RB binding protein 6, ubiquitin ligase
Chromosome : CHR 16: 245,395,86-245,728,62
Locus : 16p12.1
Alt. Genes : FEM1B
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