The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RBFOX1-20-RE | 20 (40 μL) | 200 μL |  |
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| RBFOX1-20-OR | 20 (40 μL) | 200 μL |  |
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| RBFOX1-20-GO | 20 (40 μL) | 200 μL |  |
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| RBFOX1-20-GR | 20 (40 μL) | 200 μL |  |
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| RBFOX1-20-AQ | 20 (40 μL) | 200 μL |  |
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The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Symbol : RBFOX1
Gene Name : RNA binding fox-1 homolog 1
Chromosome : CHR 16: 523,974,8-771,334,2
Locus : 16p13.3
Alt. Genes : ZNF263
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