This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RFC1-20-RE | 20 (40 μL) | 200 μL |  |
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| RFC1-20-OR | 20 (40 μL) | 200 μL |  |
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| RFC1-20-GO | 20 (40 μL) | 200 μL |  |
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| RFC1-20-GR | 20 (40 μL) | 200 μL |  |
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| RFC1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Gene Symbol : RFC1
Gene Name : Replication factor C subunit 1
Chromosome : CHR 4: 393,663,80-392,874,48
Locus : 4p14
Alt. Genes : PREB
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