This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RGS18-20-RE | 20 (40 μL) | 200 μL |  |
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| RGS18-20-OR | 20 (40 μL) | 200 μL |  |
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| RGS18-20-GO | 20 (40 μL) | 200 μL |  |
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| RGS18-20-GR | 20 (40 μL) | 200 μL |  |
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| RGS18-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : RGS18
Gene Name : Regulator of G protein signaling 18
Chromosome : CHR 1: 192,158,461-192,187,171
Locus : 1q31.2
Alt. Genes : CELA3A
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