The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF111-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF111-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF111-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF111-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF111-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Symbol : RNF111
Gene Name : Ring finger protein 111
Chromosome : CHR 15: 589,875,87-590,974,18
Locus : 15q22.1-q22.2
Alt. Genes : HIPK3
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