The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF128-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF128-20-OR | 20 (40 μL) | 200 μL |  |
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| RNF128-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF128-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF128-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Symbol : RNF128
Gene Name : Ring finger protein 128, E3 ubiquitin protein ligase
Chromosome : CHR X: 106,693,837-106,797,015
Locus : Xq22.3
Alt. Genes : LINC01587
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